The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions

  • Daugaard M
  • Rohde M
  • Jäättelä M
  • 313


    Mendeley users who have this article in their library.
  • 565


    Citations of this article.


The human heat shock protein 70 (Hsp70) family contains at least eight homologous chaperone proteins. Endoplasmatic reticulum and mitochondria have their specific Hsp70 proteins, whereas the remaining six family members reside mainly in the cytosol and nucleus. The requirement for multiple highly homologous although different Hsp70 proteins is still far from clear, but their individual and tissue-specific expression suggests that they are assigned distinct biological tasks. This concept is supported by the fact that mice knockout for different Hsp70 genes display remarkably discrete phenotypes. Moreover, emerging data suggest that individual Hsp70 proteins can bring about non-overlapping and chaperone-independent functions essential for growth and survival of cancer cells. This review summarizes our present knowledge of the individual members of human Hsp70 family and elaborate on the functional differences between the cytosolic/nuclear representatives. © 2007 Federation of European Biochemical Societies.

Author-supplied keywords

  • Cancer
  • Cell death
  • Evolution
  • Gene expression
  • Heat shock proteins
  • Thermotolerance

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Mads Daugaard

  • Mikkel Rohde

  • Marja Jäättelä

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free