Helicobacter pylori: gastric cancer and beyond.

  • Polk D
  • Peek R
  • 5


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Helicobacter pylori is the dominant species of the human gastric microbiome, and colonization causes a persistent inflammatory response. H. pylori-induced gastritis is the strongest singular risk factor for cancers of the stomach; however, only a small proportion of infected individuals develop malignancy. Carcinogenic risk is modified by strain-specific bacterial components, host responses and/or specific host-microbe interactions. Delineation of bacterial and host mediators that augment gastric cancer risk has profound ramifications for both physicians and biomedical researchers as such findings will not only focus the prevention approaches that target H. pylori-infected human populations at increased risk for stomach cancer but will also provide mechanistic insights into inflammatory carcinomas that develop beyond the gastric niche

Author-supplied keywords

  • Epidermal Growth Factor;Helicobacter Infections;H
  • Signal Transduction;Helicobacter pylori;e;Receptor

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • D Brent Polk

  • Richard M Peek

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free