Recent work revealing that our knowledge is now sufficient to build a reasonable quantitative model for the helix/coil transition in heteropolypeptides represents a watershed in research into α-helix stability, prediction and design. The opportunity is presented to design specific α-helix propensity patterns that may be used both to modify thermodynamic properties of target proteins and peptides, and for the de novo protein design. Despite these advances, the picture is not yet complete, and further studies of still poorly characterized factors are required to obtain a more precise understanding of α-helix stability. © 1995.
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