Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases

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Abstract

Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analogue 2 is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro. © 2001 Elsevier Science Ltd.

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Levin, J. I., Gu, Y., Nelson, F. C., Zask, A., DiJoseph, J. F., Sharr, M. A., … Skotnicki, J. S. (2001). Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases. Bioorganic and Medicinal Chemistry Letters, 11(2), 239–242. https://doi.org/10.1016/S0960-894X(00)00644-2

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