Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases

  • Levin J
  • Gu Y
  • Nelson F
 et al. 
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Abstract

Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analogue 2 is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro. © 2001 Elsevier Science Ltd.

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Authors

  • Jeremy I. Levin

  • Yansong Gu

  • Frances C. Nelson

  • Arie Zask

  • John F. DiJoseph

  • Michele A. Sharr

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