High bone density in adolescents with obesity is related to fat mass and serum leptin concentrations

  • Maggio A
  • Belli D
  • Puigdefabregas J
 et al. 
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OBJECTIVES: Obesity has been associated with increased bone mass, but the mechanisms involved are still poorly understood. We aimed to explore the relation between bone mineral density and factors known to influence bone formation in obese and lean adolescents. METHODS: We recruited 24 obese and 25 lean adolescents in a case-control study. Total body bone mineral density (TB-BMD) z scores and body composition were determined using dual-energy x-ray absorptiometry. We measured 25-hydroxyvitamin D (25-OH-D), glucose, insulin, and leptin concentrations. Physical activity (PA) level was quantified using accelerometer. RESULTS: TB-BMD z score was higher, whereas 25-OH-D and PA levels were lower in obese compared with lean subjects (TB-BMD z score 1.06 ± 0.96 vs 0.26 ± 0.91, P = 0.004; 25-OH-D 9.9 ± 6.4 vs 18.5 ± 7.4 ng mL, P 

Author-supplied keywords

  • Bone mineral density
  • Leptin
  • Obesity
  • Physical activity
  • Vitamin D

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  • Albane B R Maggio

  • Dominique C. Belli

  • Julie Wacker Bou Puigdefabregas

  • René Rizzoli

  • Nathalie J. Farpour-Lambert

  • Maurice Beghetti

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