High GINS2 transcript level predicts poor prognosis and correlates with high histological grade and endocrine therapy resistance through mammary cancer stem cells in breast cancer patients

  • M. Z
  • Y. Z
  • X. Y
 et al. 
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Abstract

GINS2, a subunit of the GINS complex, is overexpressed in lung adenocarcinoma and metastatic breast tumor; however, its prognostic power and possible molecular mechanisms in breast cancer (BC) remain unclear. In this study, we aimed to explore the function of GINS2 in BC. The association between GINS2 transcript level and the clinical outcome of BC patients were estimated using Kaplan-Meier plots, multivariate cox regression analysis, forest plots, and receiver operating characteristics curves. Gene set enrichment analysis (GSEA) was performed to explore the mechanisms underlying the effects of the GINS2 transcript. High GINS2 transcript level was correlated with poor relapse free survival (log-rank P

Author-supplied keywords

  • *GINS2 gene
  • *breast cancer/dr [Drug Resistance]
  • *breast cancer/dt [Drug Therapy]
  • *cancer grading
  • *cancer hormone therapy
  • *cancer prognosis
  • *cancer resistance
  • *cancer stem cell
  • *mammary cancer stem cell XT - breast cancer / dr
  • adult
  • article
  • breast cancer/dt [Drug Therapy]
  • cancer patient
  • cancer recurrence
  • cancer survival
  • controlled study
  • disease association
  • disease specific survival
  • distant metastasis free survival
  • down regulation
  • estrogen receptor/ec [Endogenous Compound]
  • female
  • gene
  • gene function
  • gene mutation
  • gene overexpression
  • gene set enrichment analysis
  • genetic analysis
  • genetic association
  • human
  • lung metastasis
  • protein p53/ec [Endogenous Compound]
  • recurrence free survival
  • tamoxifen/do [Drug Dose]
  • tamoxifen/dt [Drug Therapy]
  • tumor marker/ec [Endogenous Compound]
  • tumor suppressor gene
  • tumor volume
  • upregulation

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Authors

  • Zheng M.

  • Zhou Y.

  • Yang X.

  • Tang J.

  • Wei D.

  • Zhang Y.

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