High performance separation of sparingly aqua-/lipo-soluble bioactive compounds with an ionic liquid-based biphasic system

  • Cao Y
  • Xing H
  • Yang Q
 et al. 
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Abstract

Sepn. of high value bioactive compds. is a viable route to make full use of the biomass resources and improve the profitability. However, the sparing aqua- and lipo-soly. of the bioactive compds. makes their sepn. really challenging. Considering that ionic liqs. show good soly. of biomass and could easily form biphasic systems with org. solvents, an ionic liq. (IL)-based biphasic system consisting of ionic liq., water and Et acetate is proposed in this study. Ginkgolide homologs were selected as model compds. to evaluate its practicality. Adequate distribution coeffs., relatively high extn. capacity and selectivity were obtained with the novel biphasic system. The improved distribution coeffs. of the ginkgolides are mainly attributed to the multiple interactions between ginkgolide and IL, which were confirmed by means of quantum chem. calcns. Moreover, the effect of the interactions between ginkgolides and the extn. solvent on the selectivity coeff. was studied by measuring the Kamlet-Taft parameters of the extn. solvent. Based on the results of fractional extn., which was simulated by calcn. and validated by expts., as well as the comparison of org. solvent consumption, the employed IL-based extn. would be a valid and clean method as an alternative to chromatog. methods for sepg. bioactive compds. in large-scale operations. It is noteworthy that the amt. of org. solvents consumed with this method was supposed to be less than 1/11 of the most widely used chromatog. method. [on SciFinder(R)]

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