High Runx1 levels promote a reversible, more-differentiated cell state in hair-follicle stem cells during quiescence

  • Lee S
  • Sada A
  • Zhang M
 et al. 
  • 27


    Mendeley users who have this article in their library.
  • 8


    Citations of this article.


Quiescent hair follicle (HF) bulge stem cells (SCs) differentiate to early progenitor (EP) hair germ (HG) cells, which divide to produce transit-amplifying matrix cells. EPs can revert to SCs upon injury, but whether this dedifferentiation occurs in normal HF homeostasis (hair cycle) and the mechanisms regulating both differentiation and dedifferentiation are unclear. Here, we use lineage tracing, gain of function, transcriptional profiling, and functional assays to examine the role of observed endogenous Runx1 level changes in the hair cycle. We find that forced Runx1 expression induces hair degeneration (catagen) and simultaneously promotes changes in the quiescent bulge SC transcriptome toward a cell state resembling the EP HG fate. This cell-state transition is functionally reversible. We propose that SC differentiation and dedifferentiation are likely to occur during normal HF degeneration and niche restructuring in response to changes in endogenous Runx1 levels associated with SC location with respect to the niche. © 2014 The Authors.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • SongEun Lee

  • Aiko Sada

  • Meng Zhang

  • David J. McDermitt

  • ShuYang Lu

  • Kenneth J. Kemphues

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free