Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis

  • Mondelli V
  • Pariante C
  • Navari S
 et al. 
  • 88


    Mendeley users who have this article in their library.
  • 77


    Citations of this article.


This study investigated the relationship between cortisol secretion and hippocampal volume in first-episode psychosis and healthy controls. Hippocampal volume was measured by magnetic resonance imaging (MRI) in 24 first-episode psychosis patients and in 18 healthy controls, together with diurnal cortisol levels. Twelve patients received a second MRI scan at 3-month follow-up. Diurnal cortisol levels were inversely correlated with left hippocampal volume in patients, both at baseline and at follow-up, while no correlation was found in controls. Our findings suggest that smaller hippocampal volume in first-episode psychosis can partly be explained by stress-related processes in the brain, as measured by cortisol hyper-secretion. ?? 2009 Elsevier B.V.

Author-supplied keywords

  • Cortisol
  • Glucocorticoids
  • HPA axis
  • Hippocampus
  • Psychosis
  • Schizophrenia

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Valeria Mondelli

  • Carmine M. Pariante

  • Serena Navari

  • Monica Aas

  • Alessandro D'Albenzio

  • Marta Di Forti

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free