Highly accelerated cardiac MRI using iterative SENSE reconstruction: initial clinical experience

  • Allen B
  • Carr M
  • Botelho M
 et al. 
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To evaluate the qualitative and quantitative performance of an accelerated cardiovascular MRI (CMR) protocol that features iterative SENSE reconstruction and spatio-temporal L1-regularization (IS SENSE). Twenty consecutively recruited patients and 9 healthy volunteers were included. 2D steady state free precession cine images including 3-chamber, 4-chamber, and short axis slices were acquired using standard parallel imaging (GRAPPA, acceleration factor = 2), spatio-temporal undersampled TSENSE (acceleration factor = 4), and IS SENSE techniques (acceleration factor = 4). Acquisition times, quantitative cardiac functional parameters, wall motion abnormalities (WMA), and qualitative performance (scale: 1-poor to 5-excellent for overall image quality, noise, and artifact) were compared. Breath-hold times for IS SENSE (3.0 +/- 0.6 s) and TSENSE (3.3 +/- 0.6) were both reduced relative to GRAPPA (8.4 +/- 1.7 s, p < 0.001). No difference in quantitative cardiac function was present between the three techniques (p = 0.89 for ejection fraction). GRAPPA and IS SENSE had similar image quality (4.7 +/- 0.4 vs. 4.5 +/- 0.6, p = 0.09) while, both techniques were superior to TSENSE (quality: 4.1 +/- 0.7, p < 0.001). GRAPPA WMA agreement with IS SENSE was good (kappa > 0.60, p < 0.001), while agreement with TSENSE was poor (kappa < 0.40, p < 0.001). IS SENSE is a viable clinical CMR acceleration approach to reduce acquisition times while maintaining satisfactory qualitative and quantitative performance.

Author-supplied keywords

  • *Accelerated MRI
  • *Algorithms
  • *Cardiac gated imaging techniques
  • *Cardiac magnetic resonance imaging
  • *Stroke Volume
  • *Ventricular Function, Left
  • *Ventricular function
  • Adult
  • Aged
  • Artifacts
  • Breath Holding
  • Case-Control Studies
  • Female
  • Heart Diseases/*diagnostic imaging/physiopathology
  • Humans
  • Image Interpretation, Computer-Assisted/*methods
  • Magnetic Resonance Imaging, Cine/*methods
  • Male
  • Middle Aged
  • Nonlinear Dynamics
  • Predictive Value of Tests
  • Reproducibility of Results
  • Systole
  • Time Factors

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  • B D Allen

  • M Carr

  • M P Botelho

  • A A Rahsepar

  • M Markl

  • M O Zenge

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