High-resolution inter-subject averaging and a surface-based coordinate system.

  • Fischl B
  • Sereno M
  • Tootell R
 et al. 
  • 194

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Abstract

The neurons of the human cerebral cortex are arranged in a highly folded sheet, with the majority of the cortical surface area buried in folds. Cortical maps are typically arranged with a topography oriented parallel to the cortical surface. Despite this unambiguous sheetlike geometry, the most commonly used coordinate systems for localizing cortical features are based on 3-D stereotaxic coordinates rather than on position relative to the 2-D cortical sheet. In order to address the need for a more natural surface-based coordinate system for the cortex, we have developed a means for generating an average folding pattern across a large number of individual subjects as a function on the unit sphere and of nonrigidly aligning each individual with the average. This establishes a spherical surface-based coordinate system that is adapted to the folding pattern of each individual subject, allowing for much higher localization accuracy of structural and functional features of the human brain.

Author-supplied keywords

  • atlas
  • coordinate systems
  • intersubject averaging

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Authors

  • B Fischl

  • M I Sereno

  • R B H Tootell

  • a M Dale

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