High-throughput protein crystallization

  • Hui R
  • Edwards A
  • 171


    Mendeley users who have this article in their library.
  • 76


    Citations of this article.


High-throughput structural biology is a focus of a number of academic and pharmaceutical laboratories around the world. The use of X-ray crystallography in these efforts is critically dependent on high-throughput protein crystallization. The application of current protocols yields crystal leads for approximately 30% of the input proteins and well-diffracting crystals for a smaller fraction. Increasing the success rate will require a multidisciplinary approach that must invoke techniques from molecular biology, protein biochemistry, biophysics, artificial intelligence, and automation. © 2003 Published by Elsevier Science (USA).

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Raymond Hui

  • Aled Edwards

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free