Histone acetylation in heterochromatin assembly

  • Kim J
  • Workman J
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Abstract

Histone acetylation is generally considered a mark involved in activating gene expression by making chromatin structures less compact. In the April 1, 2010, issue of Genes & Development, Xhemalce and Kouzarides (pp. 647-652) demonstrate that the acetylation of histone H3 at Lys 4 (H3K4) plays a role in the formation of repressive heterochromatin in Schizosaccharomyces pombe. H3K4 acetylation mediates a switch of chromodomain proteins associated with methylated H3K9 during heterochromatin assembly.

Author-supplied keywords

  • Chromodomain switch
  • H3k4ac
  • HP1
  • Heterochromatin
  • RITS complex

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Authors

  • Jeong Hoon Kim

  • Jerry L. Workman

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