We investigated the interactions between human immuno-deficiency virus (HIV) infection and aging and their effects on brain function demands by means of functional magnetic resonance imaging (fMRI). A multiple-regression model was used to study the association and interaction between fMRI measures, HIV serostatus, and age for 26 HIV-infected sub-jects and 25 seronegative subjects. Although HIV serostatus and age independently affected fMRI measures, no interac-tion occurred. Functional brain demands in HIV-positive subjects were equivalent to those of HIV-negative subjects who were 15–20 years older. Frailty parallels between HIV infection and aging could result from continued immuno-logical challenges depleting resources and triggering in-creased metabolic demands. In the future, fMRI could be a noninvasive biomarker to assess HIV infection in the brain. Biological similarities exist between aging and human immu-nodeficiency virus (HIV) infection. Both cause a frailty phe-notype characterized by generalized decreased physical function caused by enhanced vulnerability to immunological stressors (abstract 157). Financial support: Dana Foundation (Brain Immuno Imaging Award DF3857-41880 to B.A.); National Institutes of Health (grant 1K23MH081786 to B.A.; grants NS-36722 and NS-42069 to R.B. and C.L.; grant P30 MH62512 to the HIV Neurobehavioral Research Center; grants AI36214, AI29164, AI47745, AI57167, AI55276, and MH62512 to A.M. and S.L.; grants MH22005 and AI47033 to F.V.; and grants AI27670 and AI43638 to R.
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