Homeostasis of the memory T cell pool

  • Marsden V
  • Kappler J
  • Marrack P
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Memory T cells are critical for the establishment of long-term immunity. The number of memory T cells formed at the conclusion of the primary response is strongly influenced by the number of effector T cells generated in the response, but some factors can additionally enhance the efficiency and quality of memory cell recruitment. Homeostasis of the memory T cell pool depends on cytokine-mediated regulation of cell survival and proliferation. This review discusses factors that influence both the development and the maintenance of the memory T cell pool.

Author-supplied keywords

  • Immune response, contraction
  • Immunological memory
  • Interleukin-15
  • Interleukin-7
  • T cells

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  • Vanessa S. Marsden

  • John W. Kappler

  • Philippa C. Marrack

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