Skip to content
Journal article

Host innate immune response to Mycobacterium tuberculosis

Bhatt K, Salgame P...(+2 more)

Journal of Clinical Immunology, vol. 27, issue 4 (2007) pp. 347-362

  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.
  • N/A

    Views

    ScienceDirect users who have downloaded this article.
Sign in to save reference

Abstract

This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-gamma-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease.

Author-supplied keywords

  • *Host-Pathogen Interactions
  • *Immunity, Innate
  • Humans
  • Immunity, Active
  • Macrophages/*immunology
  • Mycobacterium tuberculosis/*immunology
  • Toll-Like Receptors/physiology

Cite this document

Choose a citation style from the tabs below