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Host innate immune response to Mycobacterium tuberculosis

Bhatt K, Salgame P ...see all

J Clin Immunol, vol. 27, issue 4 (2007) pp. 347-362

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Abstract

This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-gamma-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease.

Author-supplied keywords

  • *Host-Pathogen Interactions
  • *Immunity, Innate
  • Humans
  • Immunity, Active
  • Macrophages/*immunology
  • Mycobacterium tuberculosis/*immunology
  • Toll-Like Receptors/physiology

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Authors

  • K Bhatt

  • P Salgame

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