Host susceptibility to tuberculosis: Insights from a longitudinal study of gene expression in diabetes

  • H.-Q. Q
  • A.R. R
  • Y. L
 et al. 
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Abstract

Tuberculosis (TB) remains a major global disease, and diabetes, which is documented to increase susceptibility to TB threefold, is also becoming pandemic. This susceptibility has been attracting extensive research interest. The increased risk of TB in diabetes may serve as a unique model to understand host susceptibility to specific pathogens in humans. To examine this rationale, we investigated the expression of reported TB candidate genes in a longitudinal diabetes study. Two genes, HK2 and CD28, emerged as potential culprits in diabetesi ncreased TB susceptibility. © 2012 The Union.

Author-supplied keywords

  • CD28 gene
  • CD4+ T lymphocyte
  • RNA
  • T lymphocyte receptor
  • Th1 cell
  • adult
  • aged
  • article
  • blood sampling
  • clinical article
  • controlled study
  • diabetes mellitus
  • down regulation
  • female
  • follow up
  • gene
  • gene cluster
  • gene expression profiling
  • gene expression regulation
  • gene function
  • gene identification
  • genetic predisposition
  • glucose
  • glucose blood level
  • glycolysis
  • hexokinase 2 gene
  • host susceptibility
  • human
  • infection risk
  • insulin
  • insulin resistance
  • interleukin 12
  • longitudinal study
  • macrophage activation
  • male
  • priority journal
  • risk assessment
  • risk factor
  • transcription regulation
  • tuberculosis

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Authors

  • Qu H.-Q.

  • Rentfro A.R.

  • Lu Y.

  • Nair S.

  • Hanis C.L.

  • McCormick J.B.

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