Journal article

Human cancers express mutator phenotypes: origin, consequences and targeting

Nature Reviews Cancer, vol. 11, issue 6 (2011) pp. 450-457

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Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator phenotype hypothesis, the origin and consequences of a mutator phenotype, the implications for personalized medicine and the feasibility of ablating tumours by error catastrophe.

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  • Lawrence A. Loeb

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