Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells.

  • Rosnet O
  • Schiff C
  • Pébusque M
 et al. 
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Abstract

The human FLT3 cDNA was cloned from a pre-B cell line and characterized. The deduced amino acid sequence shows that FLT3 codes for a receptor-type tyrosine kinase of 993 residues, presenting a strong similarity with the corresponding mouse FLT3/FLK2 protein as well as with the receptors for colony-stimulating factor 1 (CSF1R/FMS) and steel locus factor (SLFR/KIT). An analysis of the expression of the gene using amplification of reverse transcribed FLT3 mRNA by polymerase chain reaction shows that FLT3 is expressed in various lymphohematopoietic cells and tissues, including a series of immature cell lines and leukemias of lymphocytic origin.

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  • PUI: 23949868
  • ISSN: 0006-4971
  • SCOPUS: 2-s2.0-0027301288
  • SGR: 0027301288
  • PMID: 8394751
  • ISBN: 0006-4971

Authors

  • O Rosnet

  • C Schiff

  • M J Pébusque

  • S Marchetto

  • C Tonnelle

  • Y Toiron

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