Human health risk assessment of long chain alcohols

  • Veenstra G
  • Webb C
  • Sanderson H
 et al. 
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Representative chemicals from the long chain alcohols category have been extensively tested to define their toxicological hazard properties. These chemicals show low acute and repeat dose toxicity with high-dose effects (if any) related to minimal liver toxicity. These chemicals do not show evidence of activity in genetic toxicity tests or to the reproductive system or the developing organism. These chemicals also are not sensitizers. Irritation is dependant on chain length; generally, alcohols in the range C6-C11 are considered as irritant, intermediate chain lengths (C12-C16) alcohols are considered to be mild irritants and chain lengths of C18 and above are considered non-irritants. These chemicals are broadly used across the consumer products industry with highest per person consumer exposures resulting from use in personal care products. Margins of exposure adequate for the protection of human health are documented for the uses of these chemicals. © 2008.

Author-supplied keywords

  • 1 docosonol
  • Administration, Oral
  • Algorithms
  • Animals
  • Carcinogens
  • Dogs
  • Environmental Exposure
  • Exposure assessment
  • Fatty Alcohols
  • Female
  • Health
  • Household Products
  • Human risk assessment
  • Humans
  • Inhalation Exposure
  • Irritants
  • Long chain alcohols
  • MOE
  • Male
  • Models, Statistical
  • Mutagens
  • Pregnancy
  • Quantitative Structure-Activity Relationship
  • Rats
  • Reproduction
  • Risk Assessment
  • Skin Absorption
  • Tissue Distribution
  • alcohol
  • alcohol derivative
  • animal experiment
  • article
  • controlled study
  • dose response
  • dose-response relationship
  • exposure
  • female
  • genital system
  • health hazard
  • health risk
  • hexadecanol
  • hexanol
  • lauryl alcohol
  • liver toxicity
  • male
  • nonhuman
  • octadecanol
  • public health
  • rat
  • risk assessment
  • safety
  • toxicity test
  • toxicity testing
  • toxicogenetics
  • toxicological parameters
  • toxicology
  • tridecanol
  • unclassified drug

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  • G Veenstra

  • C Webb

  • H Sanderson

  • S E Belanger

  • P Fisk

  • A Nielsen

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