Human mesenchymal stem cell transformation is associated with a mesenchymal-epithelial transition

  • Rubio D
  • Garcia S
  • De la Cueva T
 et al. 
  • 9


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Carcinomas are widely thought to derive from epithelial cells with malignant progression often associated with an epithelial-mesenchymal transition (EMT). We have characterized tumors generated by spontaneously transformed human mesenchymal cells (TMC) previously obtained in our laboratory. Immunohistopathological analyses identified these tumors as poorly differentiated carcinomas, suggesting that a mesenchymal-epithelial transition (MET) was involved in the generation of TMC. This was corroborated by microarray and protein expression analysis that showed that almost all mesenchymal-related genes were severely repressed in these TMC. Interestingly, TMC also expressed embryonic antigens and were able to integrate into developing blastocysts with no signs of tumor formation, suggesting a dedifferentiation process was associated with the mesenchymal stem cell (MSC) transformation. These findings support the hypothesis that some carcinomas are derived from mesenchymal rather than from epithelial precursors.

Author-supplied keywords

  • Animals
  • Carcinoma/metabolism/*pathology/secondary
  • Cell Dedifferentiation
  • Cell Transformation, Neoplastic/metabolism/*pathol
  • Cells, Cultured
  • Epithelial Cells/ultrastructure
  • Humans
  • Keratins/metabolism
  • Male
  • Mesenchymal Stromal Cells/metabolism/*pathology/ul
  • Mice
  • RNA, Messenger/metabolism
  • Vimentin/metabolism

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in


  • D Rubio

  • S Garcia

  • T De la Cueva

  • M F Paz

  • A C Lloyd

  • A Bernad

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free