The human T cell immune response to Epstein-Barr virus

  • Landais E
  • Saulquin X
  • Houssaint E
  • 3

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Abstract

The Epstein-Barr virus (EBV) is a gamma-herpes virus which establishes latent, life-long infection in more than 95% of the human adult population. Despite its growth transforming capacity, most carriers control EBV associated malignacies efficiently and remain free of EBV+ tumors. Though EBV is controlled by a potent immune response, this virus uses latency to persist in vivo. This review summarizes work which has been done to characterize T cell responses to EBV. The CD8 T cell responses are rather well characterized and have been shown by several groups to be highly focused towards early lytic antigens. Much less is known about CD4 T cell epitopes, due to the small size of the CD4 compartment. However, recent data indicate a control of lytic and latent cycles of EBV by specific CD4+ T cells. A clear understanding of the T cell response to EBV is important with a view to developing immunotherapies for the virus and its related malignancies.

Author-supplied keywords

  • CD4-Positive T-Lymphocytes/immunology
  • CD8-Positive T-Lymphocytes/immunology
  • Epstein-Barr Virus Infections/*immunology
  • Genome, Viral
  • Herpesvirus 4, Human/genetics/*immunology
  • Humans
  • T-Lymphocytes/*immunology/virology
  • Virus Latency

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Authors

  • E Landais

  • X Saulquin

  • E Houssaint

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