Hypertonic saline improves myocardial blood flow during CPR, but is not enhanced further by the addition of hydroxy ethyl starch

  • Breil M
  • Krep H
  • Sinn D
 et al. 
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Objective: To evaluate the effects of hypertonic saline (HS) and/or hydroxy ethyl starch (HES) on myocardial perfusion pressure (MPP) and blood flow (MBF), and cardiac index (CI) during and after cardiopulmonary resuscitation (CPR). Methods: In 32 domestic swine (13-23.5 kg) open chest CPR was initiated after 8 min of ventricular fibrillation. With the onset of CPR animals randomly received 2 ml/kg per 10 min of either HS (7.2% NaCl) or hypertonic HES saline (HHS) (6% HES 200 000/0.5 in 7.2% NaCl) or HES (6% HES 200 000/0.5 in 0.9% NaCl) or normal saline (NS) (0.9% NaCl). Haemodynamic variables were monitored continuously, and coloured microspheres were used to measure MBF and CI before cardiac arrest, during CPR, and 20, 90 and 240 min after restoration of spontaneous circulation. Results: During CPR HS and HHS significantly increased MBF in comparison to HES and NS (P

Author-supplied keywords

  • Cardiac arrest
  • Cardiopulmonary resuscitation
  • Fluid therapy
  • Myocardial blood flow
  • Post-resuscitation period
  • Sodium

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  • Martin Breil

  • Henning Krep

  • Daniel Sinn

  • Andreas Hagendorff

  • Alfred Dahmen

  • Wolfgang Eichelkraut

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