Journal article

Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals

Gupta R, Kesari A, Murthy P, Chandra R, Tandon V, Watal G ...see all

J Ethnopharmacol, vol. 99, issue 1 (2005) pp. 75-81

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Abstract

The ethanolic extract of Annona squamosa L. (Annonaceae) leaves was administered orally at different doses to normal as well as streptozotocin (STZ)-induced diabetic rats and alloxan-induced diabetic rabbits. The dose of 350 mg/kg body weight (bw) reduced the fasting blood glucose (FBG) level by 6.0% within 1 h, whereas, the peak blood glucose at 1 h during glucose tolerance test (GTT) was reduced by 17.1% in normal rats. The same dose of ethanolic extract reduced FBG by 26.8% and improved glucose tolerance by 38.5 and 40.6% at 1 and 2 h, respectively, during GTT in alloxan-induced diabetic rabbits. In STZ-diabetic rats, a fall of 13.0% in FBG and an improvement in glucose tolerance by 37.2 and 60.6% at 1 and 2 h, respectively, was observed during GTT. The dose of 350 mg/kg bw of ethanolic extract in 10-day treatment of a group of STZ-diabetic rats produced 73.3% fall in FBG level and no sugar was observed in fasting urine. Treatment of severely-diabetic rabbits for 15 days with a dose of 350 mg/kg of extract reduce FBG by 52.7% and urine sugar by 75%. It brought about fall in the level of total cholesterol (TC) by 49.3% with increase of 30.3% in high-density lipoprotein (HDL) and decrease of 71.9 and 28.7% in low-density lipoprotein (LDL) and triglycerides (TG) levels, respectively.

Author-supplied keywords

  • Animals
  • Annona/*chemistry
  • Blood Glucose/metabolism
  • Cholesterol/blood
  • Diabetes Mellitus, Experimental/drug therapy
  • Ethanol
  • Female
  • Glucose Tolerance Test
  • Glycosuria/drug therapy
  • Hypoglycemic Agents/*pharmacology/therapeutic use/
  • Lethal Dose 50
  • Male
  • Plant Extracts/pharmacology/therapeutic use/toxici
  • Plant Leaves/chemistry
  • Rabbits
  • Rats
  • Rats, Wistar
  • Solvents
  • Triglycerides/blood

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Authors

  • R K Gupta

  • A N Kesari

  • P S Murthy

  • R Chandra

  • V Tandon

  • G Watal

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