Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma

  • Kleinman M
  • Greives M
  • Churgin S
 et al. 
  • 29

    Readers

    Mendeley users who have this article in their library.
  • 136

    Citations

    Citations of this article.

Abstract

The mechanism of neovascularization during the proliferative phase of infantile hemangioma is poorly understood. It is known that circulating bone marrow-derived endothelial progenitor cells (EPCs) form new blood vessels in ischemic tissues using mediators regulated by the transcription factor, HIF-1alpha. Mobilization of EPCs is enhanced by VEGF-A, matrix metalloproteinase (MMP)-9, and estrogen, whereas homing is secondary to localized expression of stromal cell-derived factor-1alpha (SDF-1alpha). We examined whether these mediators of EPC trafficking are upregulated during the proliferation of infantile hemangioma.

Author-supplied keywords

  • Chemokines
  • Endothelial progenitor cells
  • Hemangioma
  • Hypoxia
  • Vasculogenesis

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Mark E. Kleinman

  • Matthew R. Greives

  • Samara S. Churgin

  • Keith M. Blechman

  • Eric I. Chang

  • Daniel J. Ceradini

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free