Identification of cardiac dysfunction in sepsis with B-type natriuretic peptide

  • Turner K
  • Moore L
  • Todd S
 et al. 
  • 35

    Readers

    Mendeley users who have this article in their library.
  • 30

    Citations

    Citations of this article.

Abstract

Background: B-type natriuretic peptide (BNP) is secreted in response to myocardial stretch and has been used clinically to assess volume overload and predict death in congestive heart failure. More recently, BNP elevation has been demonstrated with septic shock and is predictive of death. How BNP levels relate to cardiac function in sepsis remains to be established. Study Design: Retrospective review of prospectively gathered sepsis database from a surgical ICU in a tertiary academic hospital. Initial BNP levels, patient demographics, baseline central venous pressure levels, and in-hospital mortality were obtained. Transthoracic echocardiography was performed during initial resuscitation per protocol. Results: During 24 months ending in September 2009, two hundred and thirty-one patients (59 ± 3 years of age, 43% male) were treated for sepsis. Baseline BNP increased with initial sepsis severity (ie, sepsis vs severe sepsis vs septic shock, by ANOVA; p < 0.05) and was higher in those who died vs those who lived (by Fisher's exact test; p < 0.05). Of these patients, 153 (66%) had early echocardiography. Low ejection fraction (

Author-supplied keywords

  • B-type natriuretic peptide
  • BNP
  • C-reactive protein
  • CRP
  • CVP
  • EF
  • SIRS
  • central venous pressure
  • ejection fraction
  • systemic inflammatory response syndrome

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Krista L. Turner

  • Laura J. Moore

  • S. Rob Todd

  • Joseph F. Sucher

  • Stephen A. Jones

  • Bruce A. McKinley

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free