Identification and characterization of a prostaglandin transporter

  • Kanai N
  • Lu R
  • Satriano J
 et al. 
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Abstract

Carrier-mediated prostaglandin transport has been postulated to occur in many tissues. On the basis of sequence homology, the protein of unknown function encoded by the rat matrin F/G complementary DNA was predicted to be an organic anion transporter. Expression of the matrin F/G complementary DNA in HeLa cells or Xenopus oocytes conferred the property of specific transport of prostaglandins. The tissue distribution of matrin F/G messenger RNA and the sensitivity of matrin F/G-induced prostaglandin transport to inhibitors were similar to those of endogenous prostaglandin transport. The protein encoded by the matrin F/G complementary DNA is thus preferably called PGT because it is likely to function as a prostaglandin transporter.

Author-supplied keywords

  • Amino Acid Sequence
  • Animal
  • Base Sequence
  • Biological Transport/drug effects
  • Carrier Proteins/chemistry/genetics/*metabolism
  • Codon
  • Colon/metabolism
  • DNA, Complementary/genetics
  • DNA-Binding Proteins/chemistry/genetics/*metabolis
  • Epithelium/metabolism
  • Hela Cells
  • Human
  • Kidney Medulla/metabolism
  • Molecular Sequence Data
  • Prostaglandins/*metabolism
  • RNA, Messenger/analysis
  • Rats
  • Support, Non-U.S. Gov't
  • Support, U.S. Gov't, P.H.S.
  • Xenopus

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Authors

  • N Kanai

  • R Lu

  • J A Satriano

  • Y Bao

  • A W Wolkoff

  • V L Schuster

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