Identification and characterization of a prostaglandin transporter

  • Kanai N
  • Lu R
  • Satriano J
 et al. 
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Abstract

Carrier-mediated prostaglandin transport has been postulated to occur in many tissues. On the basis of sequence homology, the protein of unknown function encoded by the rat matrin F/G complementary DNA was predicted to be an organic anion transporter. Expression of the matrin F/G complementary DNA in HeLa cells or Xenopus oocytes conferred the property of specific transport of prostaglandins. The tissue distribution of matrin F/G messenger RNA and the sensitivity of matrin F/G-induced prostaglandin transport to inhibitors were similar to those of endogenous prostaglandin transport. The protein encoded by the matrin F/G complementary DNA is thus preferably called PGT because it is likely to function as a prostaglandin transporter.

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Authors

  • Naoaki Kanai

  • Run Lu

  • Joseph A. Satriano

  • Yi Bao

  • Allan W. Wolkoff

  • Victor L. Schuster

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