Identification of genetic variants associated with response to statin therapy.

  • Mega J
  • Morrow D
  • Brown A
 et al. 
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Abstract

The purpose of this study was to test the association between polymorphisms in genes involved in either LDL cholesterol (LDL-C) metabolism or statin pharmacokinetics and LDL-C reduction with statins.

Author-supplied keywords

  • Acute Coronary Syndrome
  • Acute Coronary Syndrome: drug therapy
  • Acute Coronary Syndrome: genetics
  • Acute Coronary Syndrome: metabolism
  • Apolipoproteins E
  • Apolipoproteins E: genetics
  • Apolipoproteins E: metabolism
  • Biotransformation
  • Biotransformation: genetics
  • Cholesterol
  • Genetic
  • Haplotypes
  • Heptanoic Acids
  • Heptanoic Acids: pharmacokinetics
  • Heptanoic Acids: therapeutic use
  • Heterozygote
  • Homozygote
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors: ph
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors: th
  • LDL
  • LDL: blood
  • Lipid Metabolism
  • Lipid Metabolism: drug effects
  • Lipid Metabolism: genetics
  • P-Glycoprotein
  • P-Glycoprotein: genetics
  • P-Glycoprotein: metabolism
  • Phenotype
  • Polymorphism
  • Practice Guidelines as Topic
  • Pravastatin
  • Pravastatin: pharmacokinetics
  • Pravastatin: therapeutic use
  • Pyrroles
  • Pyrroles: pharmacokinetics
  • Pyrroles: therapeutic use
  • Treatment Outcome

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Authors

  • Jessica L Mega

  • David A Morrow

  • Alison Brown

  • Christopher P Cannon

  • Marc S Sabatine

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