Background: Flavonoids are natural phenolic compounds with antioxidant, anti-inflammatory and antimicrobial capacity. This study aimed to investigate the effects of different flavonoids for potential use in periodontal applications. Materials and Methods: Cultures of Staphylococcus epidermidis or primary human gingival fibroblasts (HGF) were treated with different doses of chrysin, diosmetin, galangin, quercitrin and taxifolin. The effect of these molecules was evaluated on S. epidermidis growth rate and on HGF viability, gene expression, collagen production, reactive oxygen species (ROS) levels, wound healing and matrix metalloproteinase-1 (MMP1) and metallopeptidase inhibitor-1 (TIMP1) production. Results: Among all the screened flavonoids, quercitrin showed the most promising biological effects, both in HGF and in S. epidermidis. Thus, quercitrin was not toxic for HGF, increased collagen IIIα1, decorin and dowregulated interleukin-6 mRNA levels, decreased the expression of pro-fibrotic markers during wound healing, decreased ROS levels in basal and stimulated conditions and decreased the MMP1/TIMP1 ratio. Quercitrin also decreased bacterial growth rate. Conclusion: Results suggest that quercitrin could contribute to protect and recover the integrity of gingival tissues, thus, displaying a potential use for periodontal disease treatment or to functionalize dental implant abutments to improve soft tissue integration. Further studies are required to confirm the role of quercitrin in gingival tissues.
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