IgG4 immune response in Churg-Strauss syndrome

  • Vaglio A
  • Strehl J
  • Manger B
 et al. 
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Abstract

Objective T-helper type 2 responses are crucial in Churg–Strauss syndrome (CSS) and may enhance the production of IgG4 antibodies. The authors assessed the IgG4 immune response in CSS patients. Methods The authors included 46 consecutive patients with CSS (24 with active and 22 with quiescent disease), 26 with granulomatosis with polyangiitis (GPA, Wegener’s), 25 with atopic asthma and 20 healthy controls and determined serum IgG, IgM, IgA, IgE and IgG subclass levels. Tissue infi ltration by IgG4 plasma cells was assessed in nine patients with CSS, 10 with GPA, 22 with chronic sinusitis (11 with and 11 without eosinophilia). Results IgG4 levels were markedly higher in active CSS patients than in controls (p

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Authors

  • Augusto Vaglio

  • Johanna D. Strehl

  • Bernhard Manger

  • Federica Maritati

  • Federico Alberici

  • Christian Beyer

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