The Ileal Lipid Binding Protein Is Required for Efficient Absorption and Transport of Bile Acids in the Distal Portion of the Murine Small Intestine

  • Praslickova D
  • Torchia E
  • Sugiyama M
 et al. 
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Abstract

The ileal lipid binding protein (ilbp) is a cytoplasmic protein that binds bile acids with high affinity. However evidence demonstrating the role of this protein in bile acid transport and homeostasis is missing. We created a mouse strain lacking ilbp (Fabp6(-/-) mice) and assessed the impact of ilbp deficiency on bile acid homeostasis and transport in vivo. Elimination of ilbp increased fecal bile acid excretion (54.2%, P

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Authors

  • Dana Praslickova

  • Enrique C. Torchia

  • Michael G. Sugiyama

  • Elijah J. Magrane

  • Brittnee L. Zwicker

  • Lev Kolodzieyski

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