Imaging B-Amyloid burden in aging and dementia

  • Rowe C
  • Ng S
  • Gong S
 et al. 
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Abstract

Objective: To compare brain ? -amyloid (A ) burden measured with [11 ? C]Pittsburgh Com- pound B (PIB) PET in normal aging, Alzheimer disease (AD), and other dementias. Methods: Thirty- three subjects with dementia (17 AD, 10 dementia with Lewy bodies [DLB], 6 frontotemporal dementia [FTD]), 9 subjects with mild cognitive impairment (MCI), and 27 age-matched healthy control subjects (HCs) were studied. A ? burden was quantified using PIB distribution volume ratio. Results: Cortical PIB binding was markedly elevated in every AD subject regardless of disease severity, gener- ally lower and more variable in DLB, and absent in FTD, whereas subjects with MCI presented either an “AD-like” (60%) or normal pattern. Binding was greatest in the precuneus/posterior cingulate, frontal cortex, and caudate nuclei, followed by lateral temporal and parietal cortex. Six HCs (22%) showed cortical uptake despite normal neuropsychological scores. PIB binding did not correlate with dementia severity in AD or DLB but was higher in subjects with an APOE-?4 allele. In DLB, binding correlated inversely with the interval from onset of cognitive impairment to diagnosis. Conclusions: Pittsburgh Compound B PET findings match histopathologic reports of ? -amyloid (A ) ? distribution in aging and dementia. Noninvasive longitudinal studies to better understand the role of amyloid deposition in the course of neurodegeneration and to determine if A ? deposition in nonde- mented subjects is preclinical AD are now feasible. Our findings also suggest that A may influence the development of dementia with Lewy bodies, and therefore strategies to reduce A may benefit ? ? this condition.

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Authors

  • Christopher C. Rowe

  • S Ng

  • S. J. Gong

  • Kerryn E Pike

  • G. Savage

  • T. F. Cowie

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