Immunity to rotavirus infection in mice

  • Franco M
  • Greenberg H
  • 2

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Recent findings from our laboratory regarding the immune response of mice to rotavirus (a mucosal pathogen) show that although in most situations an acquired (T or B cell or both) response is necessary for elimination of primary rotavirus infection, unidentified innate mechanisms can also play a role in some mouse strains. Similar to what is seen with many other viruses, CD8+ T cells appear to provide the first but not the exclusive mechanism that mediates clearance of a primary rotavirus infection. Antibodies are the critical mediators of prevention against rotavirus reinfection. Nonneutralizing IgA monoclonal antibodies directed against VP6 (an internal structural rotavirus protein) can mediate immunity against rotaviruses in vivo. Rotavirus-specific CD8+ T cells can mediate their antiviral effect in the absence of perforin, fas, or interferon-gamma and are preferentially represented in the subset that expresses high levels of the enteric mucosal homing receptor alpha4beta7

Author-supplied keywords

  • ANTIBODIES
  • ANTIGENS
  • Animal
  • Animals
  • Antibodies
  • Antigens
  • CD8-Positive T-Lymphocytes
  • Capsid
  • Capsid Proteins
  • Cells
  • Disease Models
  • IGA
  • IMMUNITY
  • INFECTION
  • Immunity
  • Mice
  • Monoclonal
  • Mucosal
  • Non-P.H.S.
  • Non-U.S.Gov't
  • P.H.S.
  • Proteins
  • REVIEW
  • Research Support
  • Rotavirus Infections
  • U.S.Gov't
  • Viral
  • Viruses
  • X
  • antibody
  • b-cell
  • immunology
  • receptor
  • structural

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

  • PMID: 10099121

Authors

  • M A Franco

  • H B Greenberg

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free