Immunodeficiency diseases caused by defects in phagocytes.

  • Lekstrom-Himes J
  • Gallin J
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Abstract

Primary phagocytic defects must be included in the differential diagnosis of recurrent infection and fever in a child and occasionally in an adult. Early diagnosis is essential, because manifestations of infection are usually blunted and rapid intervention can be lifesaving. In general, patients are identified at a young age on the basis of their susceptibility to normally nonpathogenic bacteria or fungi. In some cases, the infectious agents point to the disorder (Table 1): catalase-positive microorganisms and aspergillosis species are characteristic of chronic granulomatous disease,1 and atypical mycobacteria suggest a defect in the interferon-γ–interleukin-12 axis.2 These bacterial infections contrast with the . . .

Author-supplied keywords

  • Cell Adhesion
  • Chronic
  • Chronic: immunology
  • Granulomatous Disease
  • Humans
  • Immunologic Deficiency Syndromes
  • Immunologic Deficiency Syndromes: etiology
  • Immunologic Deficiency Syndromes: genetics
  • Immunologic Deficiency Syndromes: immunology
  • Interferon
  • Interferon-gamma
  • Interferon-gamma: physiology
  • Interferon: physiology
  • Neutropenia
  • Neutropenia: congenital
  • Phagocytes
  • Phagocytes: physiology
  • Receptors
  • Signal Transduction

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Authors

  • J A Lekstrom-Himes

  • J I Gallin

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