Primary phagocytic defects must be included in the differential diagnosis of recurrent infection and fever in a child and occasionally in an adult. Early diagnosis is essential, because manifestations of infection are usually blunted and rapid intervention can be lifesaving. In general, patients are identified at a young age on the basis of their susceptibility to normally nonpathogenic bacteria or fungi. In some cases, the infectious agents point to the disorder (Table 1): catalase-positive microorganisms and aspergillosis species are characteristic of chronic granulomatous disease,1 and atypical mycobacteria suggest a defect in the interferon-γ–interleukin-12 axis.2 These bacterial infections contrast with the . . .
CITATION STYLE
Lekstrom-Himes, J. A., & Gallin, J. I. (2000). Immunodeficiency Diseases Caused by Defects in Phagocytes. New England Journal of Medicine, 343(23), 1703–1714. https://doi.org/10.1056/nejm200012073432307
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