Immunotherapy for malignant glioma: Current approaches and future directions

  • C.W. S
  • Sikorski C
  • Lesniak M
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Abstract

Traditional therapies for the treatment of malignant glioma have failed to make appreciable gains regarding patient outcome in the last decade. Therefore, immunotherapeutic approaches have become increasingly popular in the treatment of this cancer. This article reviews general immunology of the central nervous system and the immunobiology of malignant glioma to provide a foundation for understanding the rationale behind current glioma immunotherapies. A review of currently implemented immunological treatments is then provided with special attention paid to the use of vaccines, gene therapy, cytokines, dendritic cells and viruses. Insights into future and developing avenues of glioma immunotherapy, such as novel delivery systems, are also discussed. © 2005 W. S. Maney & Son Ltd.

Author-supplied keywords

  • *cancer immunotherapy
  • *cytokine/ec [Endogenous Compound]
  • *glioma/dt [Drug Therapy]
  • *glioma/th [Therapy]
  • CD4 antigen
  • CD8 antigen
  • HLA G antigen
  • Herpes simplex virus 1
  • Newcastle disease paramyxovirus
  • Reovirus
  • T lymphocyte receptor
  • Vaccinia virus
  • adenovirus vector
  • alpha interferon/ec [Endogenous Compound]
  • antigen presenting cell
  • brain tumor/dt [Drug Therapy]
  • brain tumor/th [Therapy]
  • carmustine/dt [Drug Therapy]
  • central nervous system
  • cytokine release
  • dendritic cell
  • gene therapy
  • granulocyte macrophage colony stimulating factor/e
  • human
  • immunomodulation
  • immunotherapy
  • interleukin 12/dt [Drug Therapy]
  • interleukin 18/ec [Endogenous Compound]
  • interleukin 2/ec [Endogenous Compound]
  • interleukin 23/ec [Endogenous Compound]
  • interleukin 4/ec [Endogenous Compound]
  • major histocompatibility antigen class 1
  • major histocompatibility complex
  • neuroimmunology
  • nonhuman
  • oncolytic virus
  • review
  • transforming growth factor beta
  • viral gene delivery system
  • virus vector

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Authors

  • Sikorski C.W.

  • Christian W Sikorski

  • Maciej S Lesniak

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