The impact of common and rare EGFR mutations in response to EGFR tyrosine kinase inhibitors and platinum-based chemotherapy in patients with non-small cell lung cancer.

  • Arrieta O
  • Cardona A
  • Corrales L
 et al. 
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OBJECTIVES In non-small cell lung cancer (NSCLC), the association between common EGFR mutations (Del EX19/L858R) with EGFR tyrosine kinase inhibitors (EGFR-TKIs) has been well established. However, this has not been investigated for rare EGFR mutations or their impact on treatment response and outcome to EGFR TKIs (primary objective) and chemotherapy (secondary objective). MATERIALS AND METHODS In an observational prospective cohort, we analyzed 188 NSCLC patients from Mexico, Colombia and Costa Rica with EGFR mutations. As a first line of treatment, 66.5% received platinum-based chemotherapy. All patients received TKIs in first-line treatment or after progression to chemotherapy. The clinical-pathological characteristics as well as the f of common and rare EGFR mutations associated with treatment response were analyzed. RESULTS Of all patients, 79.5% had common and 20.5% had rare EGFR mutations. Lepidic and acinar adenocarcinomas were associated with common EGFR mutations (p=0.010). Patients with common EGFR mutations had higher response rates to EGFR-TKIs than those who had rare EGFR mutations (63.8 vs 32.4%, p

Author-supplied keywords

  • Adenocarcinoma lung cancer
  • Deletion exon 19
  • EGFR mutations
  • EGFR-tyrosine kinase inhibitors
  • L858R mutation

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  • Oscar Arrieta

  • Andrés Felipe Cardona

  • Luis Corrales

  • Alma Delia Campos-Parra

  • Roberto Sánchez-Reyes

  • Eduardo Amieva-Rivera

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