Impact of Haemophilus influenzae b (Hib) vaccination on meningitis in Central Brazil

  • Simões L
  • Andrade A
  • Laval C
 et al. 
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OBJECTIVE: To assess the impact of the Haemophilus influenzae b (Hib) conjugate vaccine in reducing the incidence of meningitis among children under five years old. METHODS: A 'before-after' design was used to compare Hib meningitis incidence rates in the pre-vaccine (July 1995 - June 1999) and post-vaccine (July 1999 - June 2001) periods in the state of Goias, central Brazil. Bacterial meningitis case definition was based on World Health Organization criteria. Incidence rates of S. pneumoniae and N. meningitidis were used for comparison purposes. Chi-squared and Student's t tests were used for statistical analysis. P-values below 0.05 were considered as statistically significant. RESULTS: 979 children with acute bacterial meningitis were detected throughout the entire period. The incidence rate of Hib meningitis decreased from 10.8 (x10(5)) in the pre-vaccine period to 2.3 (x10(5)) in the 2nd year post vaccination, leading to a risk reduction of 78%, targeted to the 7-23 months age group (p

Author-supplied keywords

  • Brazil
  • Brazil: epidemiology
  • Child
  • Conjugate
  • Conjugate: administration & dosage
  • Female
  • Haemophilus
  • Haemophilus Vaccines
  • Haemophilus Vaccines: administration & dosage
  • Haemophilus influenzae type b
  • Haemophilus influenzae type b: immunology
  • Haemophilus: epidemiology
  • Haemophilus: prevention & control
  • Humans
  • Incidence
  • Infant
  • Male
  • Meningitis
  • Preschool
  • Tetanus Toxoid
  • Tetanus Toxoid: administration & dosage
  • Vaccines

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  • Luciana Leite Pineli Simões

  • Ana Lúcia S S Andrade

  • Cristina a Laval

  • Renato M Oliveira

  • Simmone a Silva

  • Celina M T Martelli

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