Impact of human leukocyte antigen matching in liver transplantation.

  • U.P. N
  • O. G
  • J.M. L
 et al. 
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BACKGROUND: Human leukocyte antigen (HLA) compatibilities are beneficial in the setting of kidney transplantation but have demonstrated inconclusive results after liver transplantation. On the basis of recent controversial reports, the authors analyzed the impact of HLA matching in their patients after liver transplantation under modern immunosuppressive drug regimens and new HLA typing techniques with respect to outcome and adverse immunologic events., METHODS: Data from 924 transplants with complete donor-recipient HLA typing were retrospectively analyzed. Immunosuppression was commenced as either cyclosporine A- or tacrolimus-based therapy in different protocols. The follow-up period ranged from 1 to 144.8 months (median, 66 months)., RESULTS: The actuarial graft survival was 88% after 1 year and 78.7% after 5 years and was similar in tacrolimus- and cyclosporine A-treated patients. However, cyclosporine A-treated patients underwent significantly more rejection episodes. The number of HLA compatibilities had no influence on graft survival, whereas the number of acute rejections was significantly less in transplants with more HLA compatibilities (P

Author-supplied keywords

  • *HLA antigen
  • *Histocompatibility Testing
  • *Liver Transplantation/im [Immunology]
  • *leukocyte antigen
  • *liver transplantation
  • Adolescent
  • Adult
  • Aged
  • Child
  • Female
  • Graft Rejection
  • Graft Survival
  • HLA DR antigen
  • HLA typing
  • Humans
  • Immunosuppression
  • Infant
  • Male
  • Middle Aged
  • Preschool
  • adolescent
  • adult
  • aged
  • antigen detection
  • article
  • autoimmune disease
  • child
  • female
  • graft survival
  • histocompatibility
  • human
  • immune response
  • infant
  • kidney graft
  • major clinical study
  • male
  • molecular cloning
  • molecular recognition
  • priority journal
  • risk benefit analysis

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  • Neumann U.P.

  • Guckelberger O.

  • Langrehr J.M.

  • Lang M.

  • Schmitz V.

  • Theruvath T.

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