Impact of iterative reconstruction on CT coronary calcium quantification

  • Kurata A
  • Dharampal A
  • Dedic A
 et al. 
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OBJECTIVES: We evaluated the influence of sinogram-affirmed iterative reconstruction (SAFIRE) on the coronary artery calcium (CAC) score by computed tomography (CT).

MATERIALS AND METHODS: Seventy patients underwent CAC imaging by 128-slice dual-source CT. CAC volume, mass and Agatston score were calculated from images reconstructed by filtered back projection (FBP) without and with incremental degrees of the SAFIRE algorithm (10-50 %). We used the repeated measuring test and the Steel-Dwass test for multiple comparisons of values and the difference ratio among different SAFIRE groups using the FBP as reference.

RESULTS: The median Agatston score (range) decreased with incremental SAFIRE degrees: 163 (0.1 - 3,393.3), 158.4 (0.3 - 3,079.3), 137.7 (0.1 - 2,978.0), 120.6 (0 - 2,783.6), 102.6 (0 - 2,468.4) and 84.1 (0 - 2,186.9) for 0 % (FBP), 10 %, 20 %, 30 %, 40 % and 50 % SAFIRE, respectively (P 
CONCLUSION: SAFIRE noise reduction techniques significantly affected the CAC, which potentially alters perceived cardiovascular risk.

Author-supplied keywords

  • Arteriosclerosis
  • Computed tomography
  • Coronary artery disease
  • Image interpretation
  • Image processing
  • Iterative reconstruction

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  • Anoeshka Dharampal

  • Admir Dedic

  • Pim J. De Feyter

  • Gabriel P. Krestin

  • Marcel L. Dijkshoorn

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