Impact of rpoB mutations on reduced vancomycin susceptibility in Staphylococcus aureus

  • Watanabe Y
  • Cui L
  • Katayama Y
 et al. 
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Abstract

Of 38 vancomycin-intermediate Staphylococcus aureus (VISA) clinical strains, 27 (71{%}) possessed a mutation(s) in rpoB encoding the beta-subunit of RNA polymerase. Furthermore, 95.6{%} of the rifampin-resistant mutants obtained from 9 methicillin-resistant S. aureus (MRSA) clinical isolates showed decreased vancomycin susceptibilities. These data indicate the involvement of an rpoB mutation in VISA phenotype expression

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Authors

  • Yukiko Watanabe

  • Longzhu Cui

  • Yuki Katayama

  • Kishii Kozue

  • Keiichi Hiramatsu

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