Implications of previous subclinical dengue infection but not virus load in dengue hemorrhagic fever

  • Yeh W
  • Chen R
  • Wang L
 et al. 
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In a study comparing the virus load and immune reaction between patients with primary and secondary dengue-2 (DEN-2) infections in a hospital-based analysis, we found that 40.7% (55/135) of the 135 patients had secondary DEN-2 infection following a DEN-2 outbreak in southern Taiwan. Most of the secondary infections had subclinical primary dengue infections (78.2%; 43/55). Patients with secondary DEN-2 infections had lower platelet counts, and blood interferon-alpha and virus load, but significantly higher interleukin-10 (P=0.030) and anti-DEN-1 neutralization titers (P=0.013) than those with primary infection. Patients with secondary DEN-2 infection also had a higher rate of dengue hemorrhagic fever (DHF) (61.7% vs. 36.3%). A previous subclinical dengue infection is involved in the secondary DEN-2 infection associated with altered immune reaction and higher DHF rate, but lower blood virus load.

Author-supplied keywords

  • Cytokines
  • Dengue hemorrhagic fever (DHF)
  • Secondary dengue-2 (DEN-2) infection
  • Virus load

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  • Wen Ting Yeh

  • Rong Fu Chen

  • Lin Wang

  • Jien Wei Liu

  • Men Fang Shaio

  • Kuender D. Yang

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