Imprinting of the Polycomb group gene MEDEA serves as a ploidy sensor in Arabidopsis

  • Erilova A
  • Brownfield L
  • Exner V
 et al. 
  • 135

    Readers

    Mendeley users who have this article in their library.
  • 88

    Citations

    Citations of this article.

Abstract

Balanced maternal and paternal genome contributions are a requirement for successful seed development. Unbalanced contributions often cause seed abortion, a phenomenon that has been termed "triploid block." Misregulation of imprinted regulatory genes has been proposed to be the underlying cause for abnormalities in growth and structure of the endosperm in seeds with deviating parental contributions. We identified a mutant forming unreduced pollen that enabled us to investigate direct effects of unbalanced parental genome contributions on seed development and to reveal the underlying molecular mechanism of dosage sensitivity. We provide evidence that parent-of-origin-specific expression of the Polycomb group (PcG) gene MEDEA is causally responsible for seed developmental aberrations in Arabidopsis seeds with increased paternal genome contributions. We propose that imprinted expression of PcG genes is an evolutionary conserved mechanism to balance parental genome contributions in embryo nourishing tissues.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Aleksandra Erilova

  • Lynette Brownfield

  • Vivien Exner

  • Marisa Rosa

  • David Twell

  • Ortrun Mittelsten Scheid

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free