Improving Mass Spectrometer Sensitivity Using a High-Pressure Electrodynamic Ion Funnel Interface

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Abstract

We report on a new electrodynamic ion funnel that operates at a pressure of 30 torr with no loss of ion transmission. The enhanced performance compared with previous ion funnel designs optimized for pressures of <5 torr was achieved by reducing the ion funnel capacitance and increasing the RF drive frequency (1.7 MHz) and amplitude (100-170 V peak-to-peak). No degradation of ion transmission was observed for pressures from 2 to 30 torr. The ability to operate at higher pressure enabled a new tandem ion funnel mass spectrometer interface design that can accommodate a greater gas load (e.g., from an ESI source). When combined with a multicapillary inlet, the interface provided more efficient introduction of ions, resulting in a significant enhancement in mass spectrometer sensitivity and detection limits. © 2006 American Society for Mass Spectrometry.

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Ibrahim, Y., Tang, K., Tolmachev, A. V., Shvartsburg, A. A., & Smith, R. D. (2006). Improving Mass Spectrometer Sensitivity Using a High-Pressure Electrodynamic Ion Funnel Interface. Journal of the American Society for Mass Spectrometry, 17(9), 1299–1305. https://doi.org/10.1016/j.jasms.2006.06.005

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