Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma

  • Li M
  • Zhao H
  • Zhang X
 et al. 
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Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype.

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  • Meng Li

  • Hong Zhao

  • Xiaosong Zhang

  • Laura D. Wood

  • Robert A. Anders

  • Michael A. Choti

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