Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs

  • Graham D
  • Staffa J
  • Shatin D
 et al. 
  • 171


    Mendeley users who have this article in their library.
  • 607


    Citations of this article.


ContextLipid-lowering agents are widely prescribed in the United States. Reliable estimates of rhabdomyolysis risk with various lipid-lowering agents are not available.ObjectiveTo estimate the incidence of rhabdomyolysis in patients treated with different statins and fibrates, alone and in combination, in the ambulatory setting.Design, Setting, and PatientsDrug-specific inception cohorts of statin and fibrate users were established using claims data from 11 managed care health plans across the United States. Patients with at least 180 days of prior health plan enrollment were entered into the cohorts between January 1, 1998, and June 30, 2001. Person-time was classified as monotherapy or combined statin-fibrate therapy.Main Outcome MeasureIncidence rates of rhabdomyolysis per 10 000 person-years of treatment, number needed to treat, and relative risk of rhabdomyolysis.ResultsIn 252 460 patients treated with lipid-lowering agents, 24 cases of hospitalized rhabdomyolysis occurred during treatment. Average incidence per 10 000 person-years for monotherapy with atorvastatin, pravastatin, or simvastatin was 0.44 (95% confidence interval [CI], 0.20-0.84); for cerivastatin, 5.34 (95% CI, 1.46-13.68); and for fibrate, 2.82 (95% CI, 0.58-8.24). By comparison, the incidence during unexposed person-time was 0 (95% CI, 0-0.48; P = .056). The incidence increased to 5.98 (95% CI, 0.72-216.0) for combined therapy of atorvastatin, pravastatin, or simvastatin with a fibrate, and to 1035 (95% CI, 389-2117) for combined cerivastatin-fibrate use. Per year of therapy, the number needed to treat to observe 1 case of rhabdomyolysis was 22 727 for statin monotherapy, 484 for older patients with diabetes mellitus who were treated with both a statin and fibrate, and ranged from 9.7 to 12.7 for patients who were treated with cerivastatin plus fibrate.ConclusionsRhabdomyolysis risk was similar and low for monotherapy with atorvastatin, pravastatin, and simvastatin; combined statin-fibrate use increased risk, especially in older patients with diabetes mellitus. Cerivastatin combined with fibrate conferred a risk of approximately 1 in 10 treated patients per year.Published online November 22, 2004 (doi:10.1001/jama.292.21.2585).

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • David J. Graham

  • Judy A. Staffa

  • Deborah Shatin

  • Susan E. Andrade

  • Stephanie D. Schech

  • Lois La Grenade

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free