Incidence and risk factors for psoriasis in the general population

  • Huerta C
  • Rivero E
  • Rodriguez L
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OBJECTIVES: To study the clinical spectrum of psoriasis and the incidence in the general population and to identify risk factors associated with the occurrence of psoriasis. DESIGN: Prospective cohort study with nested case-control analysis. SETTING: The data source was the United Kingdom General Practice Research Database containing computerized clinical information entered by general practitioners (GPs). PATIENTS: The study population comprised patients receiving a first-ever diagnosis of psoriasis between January 1, 1996, and December 31, 1997, and free of cancer. INTERVENTIONS: Diagnosis of psoriasis was validated in a random sample of 14% of all ascertained cases requesting confirmation by the GPs. Nested case-control analysis included 3994 cases of psoriasis and a random sample of 10 000 controls frequency matched to cases by age, sex, and calendar year. MAIN OUTCOME MEASURES: Incidence rate of psoriasis and estimates of the odds ratio (OR) and 95% confidence interval (CI) for psoriasis as associated with selected risk factors. RESULTS: The incidence rate of psoriasis was 14 per 10 000 person-years. Patients with antecedents of skin disorders and skin infection within the last year carried the highest risk of developing psoriasis (OR, 3.6 [95% CI, 3.2-4.1], and OR, 2.1 [95% CI, 1.8-2.4], respectively). Also, smoking was found to be an independent risk factors for psoriasis (OR, 1.4 [95% CI, 1.3-1.6]). We did not find an association between risk of psoriasis and antecedents of stress, diabetes, hypertension, hyperlipidemia, cardiovascular disease, or rheumatoid arthritis. CONCLUSIONS: The incidence rate in our study was higher than those published in other studies, probably owing to our case definition that considered cases recorded by the GPs independently of a specialist confirmation. Our results confirm the association between psoriasis, skin disorders, and smoking

Author-supplied keywords

  • Adult
  • Aged
  • Aged,80 and over
  • Arthritis
  • Case-Control Studies
  • Cohort Studies
  • Databases,Factual
  • Disease
  • Female
  • General Practice
  • General Practitioners
  • Great Britain
  • Humans
  • Hypertension
  • Incidence
  • Infection
  • Male
  • Middle Aged
  • Odds Ratio
  • Patients
  • Population
  • Prospective Studies
  • Psoriasis
  • Research
  • Risk
  • Risk Factors
  • Skin
  • Skin Diseases
  • Smoking
  • adverse effects
  • analysis
  • complications
  • diagnosis
  • epidemiology
  • etiology
  • microbiology

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  • PMID: 18087008


  • C Huerta

  • E Rivero

  • L A Rodriguez

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