Journal article

Incidence of spontaneous abortion in clomiphene pregnancies.

Dickey R, Taylor S, Curole D, Rye P, Pyrzak R ...see all

Human reproduction (Oxford, England), vol. 11, issue 12 (1996) pp. 2623-8

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The purpose of this study was to determine whether the use of clomiphene results in a higher incidence of spontaneous abortion than occurs naturally in subfertile patients. Reproductive outcomes of 1744 clomiphene pregnancies were compared to outcomes of 3245 spontaneous pregnancies in a prospective study. Abortion was classified as clinical if a sac was seen on ultrasound or if it occurred after 6 gestational weeks, and as preclinical if a quantitative human chorionic gonadotrophin (HCG) was > or = 25 mIU and no sac was seen or abortion occurred earlier. The overall incidence of abortion was higher for clomiphene pregnancies (23.7%), compared with spontaneous pregnancies (20.4%) (P < 0.01). Preclinical abortions were increased by clomiphene for all ages (5.8 versus 3.9%, P < 0.01) and for age > or = 30 years (8.0 versus 4.9%, P < 0.001), but not for age < 30 years (3.7 versus 3.0%). Clinical abortions were increased by clomiphene for age < 30 years (15.9 versus 11.2%) (P < 0.01), but not for age > or = 30 years (20.1 versus 22.3%) or all ages (18.0 versus 16.4%). Clinical abortions occurred 22% less often following clomiphene compared with spontaneous pregnancies for patients with luteal insufficiency (18.3 versus 23.6%, P < 0.05). We conclude that the increase in abortion due to clomiphene is small and may be related to different causes for women aged < 30 and > or = 30 years, and also that clomiphene may decrease clinical abortions in patients with luteal insufficiency.

Author-supplied keywords

  • Abortion, Spontaneous
  • Abortion, Spontaneous: etiology
  • Adult
  • Clomiphene
  • Clomiphene: adverse effects
  • Clomiphene: therapeutic use
  • Female
  • Fertilization in Vitro
  • Follicle Stimulating Hormone
  • Follicle Stimulating Hormone: therapeutic use
  • Gamete Intrafallopian Transfer
  • Gestational Age
  • Humans
  • Menotropins
  • Menotropins: therapeutic use
  • Pregnancy
  • Pregnancy Outcome
  • Prospective Studies

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  • PUI: 27060730
  • PMID: 9021363
  • SCOPUS: 2-s2.0-0030482133
  • ISSN: 0268-1161
  • SGR: 0030482133


  • R P Dickey

  • S N Taylor

  • D N Curole

  • P H Rye

  • R Pyrzak

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