Increased understanding of platinum anticancer chemistry

  • Reedijk J
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The development of a few worldwide routinely used Pt(II) coordination compounds is described from a mechanistic point of view and related to the molecular aspects of Pt-DNA binding. Mechanistic knowledge developed from these studies is applied nowadays for the design and synthesis of new bifunctional and trifunctional compounds, aimed for use as improved anticancer drugs.

Author-supplied keywords

  • antitumor
  • carboplatin
  • cisplatin
  • copper
  • mechanism
  • oxaliplatin
  • ruthenium

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  • Jan Reedijk

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