Induction Of Cell Proliferation In Mammalian Inner Ear Sensory Epithelia by tralsforming growth factor alpha and epidermal growth factor

  • Yamashita H
  • Oesterle E
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Abstract

Regenerative proliferation occurs in the inner-ear sensory epithelial
of warm-blooded vertebrates after insult. To determine how this proliferation
is controlled in the mature mammalian inner ear, several growth factors
were tested for effects on progenitor-cell division in cultured mouse
vestibular sensory epithelia. Cell proliferation was induced in the
sensory epithelium by transforming growth factor alpha (TGF-alpha)
in a dose-dependent manner. Proliferation was also induced by epidermal
growth factor (EGF) when supplemented with insulin, but not EGF alone.
These observations suggest that stimulation of the EGF receptors
by TGF-alpha binding, or EGF (plus insulin) binding, stimulates cell
proliferation in the mature mammalian vestibular sensory epithelium.

Author-supplied keywords

  • Animals
  • Cell Division
  • Dose-Response Relationship
  • Drug
  • Drug Interactions
  • Epidermal Growth Factor
  • Epithelium
  • Growth Substa
  • Hair Cells
  • Ins
  • Mice
  • Mitosis
  • Organ Culture Techniques
  • Saccule a
  • Transforming
  • Up-Regulation
  • Vestibular
  • anatomy /&/ histology/drug effects
  • cytology/drug effects/growth /&/ development
  • drug effects
  • drug effects/growth /&/ development
  • pharmacology

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Authors

  • H Yamashita

  • Elizabeth C Oesterle

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