Induction Of Cell Proliferation In Mammalian Inner Ear Sensory Epithelia by tralsforming growth factor alpha and epidermal growth factor

  • Yamashita H
  • Oesterle E
  • 6


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Regenerative proliferation occurs in the inner-ear sensory epithelial
of warm-blooded vertebrates after insult. To determine how this proliferation
is controlled in the mature mammalian inner ear, several growth factors
were tested for effects on progenitor-cell division in cultured mouse
vestibular sensory epithelia. Cell proliferation was induced in the
sensory epithelium by transforming growth factor alpha (TGF-alpha)
in a dose-dependent manner. Proliferation was also induced by epidermal
growth factor (EGF) when supplemented with insulin, but not EGF alone.
These observations suggest that stimulation of the EGF receptors
by TGF-alpha binding, or EGF (plus insulin) binding, stimulates cell
proliferation in the mature mammalian vestibular sensory epithelium.

Author-supplied keywords

  • Animals
  • Cell Division
  • Dose-Response Relationship
  • Drug
  • Drug Interactions
  • Epidermal Growth Factor
  • Epithelium
  • Growth Substa
  • Hair Cells
  • Ins
  • Mice
  • Mitosis
  • Organ Culture Techniques
  • Saccule a
  • Transforming
  • Up-Regulation
  • Vestibular
  • anatomy /&/ histology/drug effects
  • cytology/drug effects/growth /&/ development
  • drug effects
  • drug effects/growth /&/ development
  • pharmacology

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • H Yamashita

  • Elizabeth C Oesterle

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free